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Probes for narcotic receptor mediated phenomena 3. Oxide bridged 5-phenylmorphans.

作者信息

Burke T R, Jacobson A E, Rice K C, Weissman B A, Silverton J V

出版信息

NIDA Res Monogr. 1984 Mar;49:109-13.

PMID:6090913
Abstract
摘要

相似文献

1
Probes for narcotic receptor mediated phenomena 3. Oxide bridged 5-phenylmorphans.麻醉受体介导现象的探针3. 氧化物桥连的5-苯基吗啉类化合物。
NIDA Res Monogr. 1984 Mar;49:109-13.
2
Oxide-bridged 5-phenylmorphans as probes for narcotic receptor mediated phenomena.
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Probes for narcotic receptor-mediated phenomena. 33. Construction of a strained trans-5,6-ring system by displacement of a nitro-activated aromatic fluorine. synthesis of the penultimate oxide-bridged phenylmorphans.用于麻醉受体介导现象的探针。33. 通过硝基活化的芳族氟的取代构建张力反式5,6-环系统。倒数第二个氧化桥连苯基吗啉的合成。
J Org Chem. 2004 Aug 6;69(16):5322-7. doi: 10.1021/jo040159k.
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Probes for narcotic receptor mediated phenomena. Part 42: synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans.阿片受体介导现象探针。第 42 部分：外消旋邻位和对位氧化桥联苯并吗啡喃的 N-甲基和 N-苯乙基类似物的合成及体外药理学特征。
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Analgesics 4. Studies on the effects of the introduction of methyl at C-17 of N-cyclopropylmethyl-normorphine: synthesis, receptor binding, in vivo activity, conformation energies.
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Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules.桥连六氢阿朴啡和异喹啉分子的体内和体外阿片样物质活性评估。
J Med Chem. 1990 Jan;33(1):245-8. doi: 10.1021/jm00163a040.
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Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: compounds with moderate to low opioid-receptor affinity.阿片受体介导现象的探针。43. 邻-a 和对-a 以及邻-b 和对-b 氧化桥联苯吗喃的改进合成和光学拆分：具有中等至低阿片受体亲和力的化合物。
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Probes for narcotic receptor mediated phenomena. 39. Enantiomeric N-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans.用于麻醉受体介导现象的探针。39. 对映体N-取代苯并呋喃并[2,3-c]吡啶-6-醇：合成及其与氧化物桥连苯吗喃的拓扑关系。
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Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation.麻醉受体介导现象的探针。48. 从非对映选择性烷基化反应得到的 C7-和 C8-取代的 5-苯吗啡烷类阿片样物质。
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Structure-activity relationships of oxygenated morphinans. III. An exploration of the effect of the aromatic oxygen and 6-keto group on antinociceptive activity, receptor affinity, and narcotic antagonism.氧化吗啡喃的构效关系。III. 芳香氧和6-酮基对抗痛活性、受体亲和力及麻醉拮抗作用影响的探究。
NIDA Res Monogr. 1982 Apr;41:86-92.

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Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - carbocyclic relatives of f-oxide-bridged phenylmorphans.麻醉受体介导现象的探针。46. N-取代的 2,3,4,9,10,10a-六氢-1H-1,4a-(亚氨基乙氧基)菲并 6-和 8-醇-桥连苯并吗啡喃的碳环类似物。
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Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: compounds with moderate to low opioid-receptor affinity.
阿片受体介导现象的探针。43. 邻-a 和对-a 以及邻-b 和对-b 氧化桥联苯吗喃的改进合成和光学拆分：具有中等至低阿片受体亲和力的化合物。
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4
Probes for narcotic receptor mediated phenomena. Part 42: synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans.阿片受体介导现象探针。第 42 部分：外消旋邻位和对位氧化桥联苯并吗啡喃的 N-甲基和 N-苯乙基类似物的合成及体外药理学特征。
Bioorg Med Chem. 2011 Jun 1;19(11):3434-43. doi: 10.1016/j.bmc.2011.04.028. Epub 2011 Apr 22.
5
PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 38. AN EXPEDITIOUS SYNTHESIS OF RAC-CIS-4a-ETHYL-2-METHYL-1,2,3,4,4a,9a-HEXAHYDROBENZOFURO[2,3-c]PYRIDIN-6-OL AND RAC-CIS-2-METHYL-4a-PHENETHYL-1,2,3,4,4a,9a-HEXAHYDROBENZOFURO[2,3-c]PYRIDIN-6-OL.用于麻醉受体介导现象的探针。38. 外消旋顺式-4a-乙基-2-甲基-1,2,3,4,4a,9a-六氢苯并呋喃并[2,3-c]吡啶-6-醇和外消旋顺式-2-甲基-4a-苯乙基-1,2,3,4,4a,9a-六氢苯并呋喃并[2,3-c]吡啶-6-醇的快速合成。
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Probes for narcotic receptor mediated phenomena. 40. N-substituted cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-8-ols.阿片受体介导现象的探针。40. N-取代的顺式-4a-乙基-1,2,3,4,4a,9a-六氢苯并呋喃[2,3-c]吡啶-8-醇。
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Probes for narcotic receptor mediated phenomena. 37. Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers.麻醉受体介导现象的探针。37. 最后一对氧化物桥连苯吗喃（邻位和对位β-异构体及其N-苯乙基类似物）的合成与阿片样物质结合亲和力，以及邻位和对位δ-异构体的N-苯乙基类似物的合成。
J Med Chem. 2008 Dec 25;51(24):7866-81. doi: 10.1021/jm800913d.