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[神经元细胞膜的新进展:跨膜离子通道结构分析的进展]

[New developments concerning the neuron cell membrane: advances in the structural analysis of transmembrane ion channels].

作者信息

Betz H

出版信息

Naturwissenschaften. 1984 Jul;71(7):363-8. doi: 10.1007/BF00410741.

Abstract

Information processing in the brain requires the activation of electrically and chemically gated ion channels in the neuronal plasma membrane. Recently, the function and the molecular composition of some of these membrane proteins have become the subject of extensive biochemical and biophysical analysis. From the currently available data, it is proposed that the architecture of different neuronal ion channels obeys common structural principles which may have resulted from a divergent evolution of a limited number of ancestor transmembrane polypeptides.

摘要

大脑中的信息处理需要激活神经元质膜中电门控和化学门控离子通道。最近,其中一些膜蛋白的功能和分子组成已成为广泛的生化和生物物理分析的主题。根据目前可得的数据,有人提出不同神经元离子通道的结构遵循共同的结构原则,这些原则可能源于有限数量的祖先跨膜多肽的趋异进化。

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