津巴布韦急性肝炎的病因

The aetiology of acute hepatitis in Zimbabwe.

作者信息

Crocchiolo P R, Caredda F, D'Arminio Monforte A, Lencioni R, Ragni M C, Cenzuales S, Farci P, Lavarini C, Latif A S

出版信息

Trans R Soc Trop Med Hyg. 1984;78(4):514-8. doi: 10.1016/0035-9203(84)90074-9.

Abstract

The cause of acute viral hepatitis in 141 patients admitted to both Infectious Diseases Hospitals in Harare (Zimbabwe) was hepatitis A in 44, hepatitis B in 86 and hepatitis Non-A Non-B in 11. The wide distribution of hepatitis A and B viruses and early exposure to both in Zimbabwe are shown by the high positivity rate for anti-HAV antibody in patients under 10 years old (87.5%) and for anti-HBs antibody in patients over 20 (60%). Among the 86 hepatitis B cases, e and delta systems were also investigated: 66 patients (76.5%) were HBeAg positive, six (7%) anti-HBe positive and 14 (16.5%) negative for both; only one was anti-delta positive. Two cases of fulminant liver failure (both occurring in HBsAg and anti-HBc IgM positive, but delta-markers negative patients) and five cases of hepatoma (only one of whom was negative for all HBV markers) are described.

摘要

在津巴布韦哈拉雷的两家传染病医院收治的141例急性病毒性肝炎患者中，病因如下：44例为甲型肝炎，86例为乙型肝炎，11例为非甲非乙型肝炎。10岁以下患者抗甲型肝炎病毒抗体阳性率高（87.5%），20岁以上患者抗乙型肝炎表面抗体阳性率高（60%），这表明甲型和乙型肝炎病毒在津巴布韦分布广泛且人们早期即接触到这两种病毒。在86例乙型肝炎病例中，还对e抗原和δ抗原系统进行了调查：66例患者（76.5%）HBeAg阳性，6例（7%）抗-HBe阳性，14例（16.5%）两者均为阴性；仅1例抗-δ阳性。文中描述了2例暴发性肝衰竭（均发生在HBsAg和抗-HBc IgM阳性但δ标志物阴性的患者中）和5例肝癌（其中仅1例所有HBV标志物均为阴性）。