Kimmig J M
Z Gastroenterol. 1984 Aug;22(8):373-8.
The efficacy of the two H2-receptor-antagonists cimetidine (2 X 400 mg/die) and ranitidine (2 X 150 mg/die) for reflux oesophagitis was compared. 128 patients with endoscopically proven reflux oesophagitis in stages I and II based on the criteria of Savary and Miller took part in the trial on an out patients basis. Both drugs healed the oesophagus lesions in 70% of the patients after 6 weeks treatment. After 12 weeks, 90% of stage I patients and 80-85% of stage II patients were completely healed with both H2-antagonists. No significant difference was seen between the two drugs either with respect to the healing of the lesions or to the symptomatic improvement.
比较了两种H2受体拮抗剂西咪替丁（每日2次，每次400毫克）和雷尼替丁（每日2次，每次150毫克）治疗反流性食管炎的疗效。128例根据萨瓦里和米勒标准经内镜证实为I期和II期反流性食管炎的患者作为门诊患者参与了该试验。两种药物在治疗6周后使70%的患者食管病变愈合。12周后，两种H2拮抗剂使90%的I期患者和80 - 85%的II期患者完全愈合。在病变愈合或症状改善方面，两种药物之间均未观察到显著差异。
