A theoretic consideration on the use of calcium antagonists in the treatment of hypertension.

A cellular basis for the reduction of contractile tension in vascular smooth muscle by calcium antagonists is described. A better understanding of the mechanisms and pathways that supply activating calcium ions to the cytoplasm will permit investigation of specific functional abnormalities that lead to hypertension. If the "leak channel" is found to be the responsible site, then antihypertensive drugs even more specific than those currently available can be designed.