Gerasimov A M, Ovchinnikov K G, Mel'nikova V M
Antibiotiki. 1984 Aug;29(8):600-4.
The ability of various antibiotics to inhibit superoxide anion(O-2)-mediated formation of adrenochrome from adrenaline and recovery of cytochrome c by xanthine oxidase was studied. In the adrenaline system (pH 10.2), aminoglycosides might be arranged, according to the inhibitory effect, in the following order: monomycin greater than gentamicin greater than kanamycin greater than lincomycin greater than streptomycin. In the xanthine oxidase system (pH 7.8), that order was the following: monomycin greater than gentamicin greater than lincomycin greater than greater than kanamycin. It was suggested that the antibiotic inhibition of the O-2-dependent processes at the essential sites of metabolism and/or the antibiotic involvement into the process of free radical oxidation initiated by O-2 in the cells might be one of the mechanisms of the drug action and toxicity with respect to the host.
研究了各种抗生素抑制超氧阴离子（O₂⁻）介导的肾上腺素生成肾上腺色素以及黄嘌呤氧化酶使细胞色素c恢复的能力。在肾上腺素系统（pH 10.2）中，根据抑制作用，氨基糖苷类抗生素可按以下顺序排列：单霉素＞庆大霉素＞卡那霉素＞林可霉素＞链霉素。在黄嘌呤氧化酶系统（pH 7.8）中，该顺序如下：单霉素＞庆大霉素＞林可霉素＞＞卡那霉素。有人提出，抗生素在代谢关键位点对O₂⁻依赖性过程的抑制作用和/或抗生素参与细胞中由O₂引发的自由基氧化过程，可能是药物对宿主产生作用和毒性的机制之一。
