Pairolero P C, Williams D E, Bergstralh E J, Piehler J M, Bernatz P E, Payne W S
Ann Thorac Surg. 1984 Oct;38(4):331-8. doi: 10.1016/s0003-4975(10)62281-3.
Three hundred forty-six patients with post-surgical non-small cell Stage I bronchogenic carcinoma were followed from 5.0 to 10.8 years (median, 7.0 years). Recurrent cancer developed in 135 patients (39%). Seventy-five recurrences were nonregional metastases (55.6%); 35 (25.9%), a subsequent primary lung cancer; and 25 (18.5%), local recurrence only. The rate of recurrent lung cancer decreased from 15.0 patients per 100 patient-years the first postoperative year to 2.3 the seventh and subsequent years. The rate of recurrence varied among the three different types of recurrent cancer. Five years after pulmonary resection, 70.0% of patients with T1 N0 neoplasms had no evidence of recurrence compared with 58.2% of patients with T2 N0 tumors (p = 0.012) and only 31.8% of patients with T1 N1 neoplasms (p less than 0.001). There was no significant difference in overall rate of recurrence among the various cell types. Currently, 174 patients are alive. Lung cancer survival (Kaplan-Meier) was 69.1% at 5 years and 61.9% at 9 years. At 2 years following detection of subsequent lung cancer, 51.8% of patients with subsequent primary lung cancer had survived lung cancer compared with 23.4% for those with local recurrence and only 8.9% for those with nonregional metastases.
346例手术后非小细胞I期支气管源性癌患者随访了5.0至10.8年（中位数为7.0年）。135例患者（39%）出现癌症复发。75例复发为非区域性转移（55.6%）；35例（25.9%）为随后发生的原发性肺癌；25例（18.5%）仅为局部复发。肺癌复发率从术后第一年每100患者年15.0例降至第七年及以后的2.3例。三种不同类型的复发性癌症的复发率各不相同。肺切除术后5年，T1 N0肿瘤患者中有70.0%无复发迹象，而T2 N0肿瘤患者为58.2%（p = 0.012），T1 N1肿瘤患者仅为31.8%（p<0.001）。不同细胞类型的总体复发率无显著差异。目前，174例患者存活。肺癌生存率（Kaplan-Meier法）5年时为69.1%，9年时为61.9%。在发现随后发生的肺癌后2年，随后发生原发性肺癌的患者中有51.8%存活，而局部复发患者为23.4%，非区域性转移患者仅为8.9%。
