Moe R D, Frankel S F, Chacko A K, Yim D W, Clark M W
Arch Otolaryngol. 1984 Nov;110(11):717-20. doi: 10.1001/archotol.1984.00800370019004.
Only 15% to 25% of cold nodules on conventional static thyroid scans are malignant. Radionuclide angiography of the thyroid and conventional static scans using sodium pertechnetate Tc 99m were performed on 114 patients who underwent thyroid surgery within a five-year period. The combined use of radionuclide angiography and conventional static scans increased the specificity for the diagnosis of thyroid carcinoma from 42% to 79% over static scans alone. The incidence of carcinoma in solitary cold nodules in our population was increased from 26% on static scans to 60% if the lesion was hypervascular on radionuclide angiography. Eighty-seven percent of hypervascular solitary cold nodules were neoplasms (carcinomas and adenomas). Hypervascularity as demonstrated by radionuclide angiography is predictive of thyroid neoplasia. The finding of a hypervascular, solitary cold nodule makes a recommendation for surgery predictive and reasonable.
在传统静态甲状腺扫描中，只有15%至25%的冷结节是恶性的。对114例在五年内接受甲状腺手术的患者进行了甲状腺放射性核素血管造影和使用高锝酸钠Tc 99m的传统静态扫描。放射性核素血管造影和传统静态扫描的联合使用使甲状腺癌诊断的特异性从单纯静态扫描的42%提高到了79%。在我们的研究人群中，孤立性冷结节的癌发生率从静态扫描时的26%增加到放射性核素血管造影显示病变为高血运时的60%。87%的高血运孤立性冷结节为肿瘤（癌和腺瘤）。放射性核素血管造影显示的高血运可预测甲状腺肿瘤。发现高血运的孤立性冷结节使得手术建议具有预测性且合理。
