衰老过程中大脑突触膜的结构和功能变化
[Structural and functional changes in the synaptic membranes of the brain during aging].
作者信息
Miliutin A A, Beliaeva E I, Bulanova K Ia, Kiriliuk A P, Lyskova T I
出版信息
Biofizika. 1984 Jul-Aug;29(4):640-2.
PMID:6091786
Abstract
Below 37 degrees the mobility of lipids in rat brain synaptic membranes evaluated by the spin probe method is higher in old (24-26 months) than in young (5-6 months) animals. The number of ouabain receptors in membranes increases with age, while maximum rate and Km values are not changed. The relation between structural state of membrane and properties of ouabain binding centers is discussed.
摘要
通过自旋探针法评估，在37摄氏度以下，老年（24 - 26个月）大鼠脑突触膜中脂质的流动性高于幼年（5 - 6个月）动物。膜中哇巴因受体的数量随年龄增加，而最大速率和米氏常数未发生变化。本文讨论了膜的结构状态与哇巴因结合中心性质之间的关系。
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