[血管加压素对成年和老年大鼠大脑突触膜中钠钾-ATP酶活性的影响]
[Effect of vasopressin on the Na,K-ATPase activity in synaptic membranes of the brain of adult and old rats].
作者信息
Potapenko R I
出版信息
Vopr Med Khim. 1987 Mar-Apr;33(2):122-5.
PMID:3037791
Abstract
Vasopressin regulated in vitro the activity of Na+, K+-ATPase in synaptic membranes from rat brain cortex and brain stem. Low concentrations of the peptide activated the enzyme, high concentrations--inhibited. The effect was most distinct in brain stem. Age-dependent effects of vasopressin on the Na+, K+-ATPase activity were observed. Basal activity of the enzyme was not altered in synaptic membranes with ageing.
摘要
血管加压素在体外调节大鼠大脑皮层和脑干突触膜中Na +，K + -ATP酶的活性。低浓度的该肽激活该酶，高浓度则抑制该酶。这种作用在脑干中最为明显。观察到血管加压素对Na +，K + -ATP酶活性的年龄依赖性作用。随着年龄增长，突触膜中该酶的基础活性未发生改变。
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