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[钙通道阻滞剂对大脑皮质毛细血管系统形态功能状态的影响]

[Effect of calcium blockers on the morphofunctional state of the capillary system of the cerebral cortex].

作者信息

Gabrielian E S, Matevosian R Sh

出版信息

Biull Eksp Biol Med. 1984 Sep;98(9):310-2.

PMID:6091809
Abstract

The use of the non-injection method for determination of the intraorgan microcirculatory bed in cats has shown that calcium channels play an important role in the functioning of precapillary sphincters, whose activity depends to a greater extent on the activity of alpha-adrenoreceptors, particularly alpha 1-receptors. The so-called "gaiting mechanism" of calcium channels plays a more essential part in the changes in the basal tone of precapillary sphincters influenced by calcium antagonists, whereas voltage-controlled and receptor-operated calcium channels are responsible for variations in the adrenergic tone of precapillary sphincters.

摘要

采用非注射法测定猫器官内微循环床的研究表明,钙通道在毛细血管前括约肌的功能中发挥着重要作用,其活性在很大程度上取决于α - 肾上腺素能受体,尤其是α1 - 受体的活性。钙通道的所谓“步速机制”在钙拮抗剂影响下毛细血管前括约肌基础张力的变化中起更重要的作用,而电压控制型和受体操纵型钙通道则负责毛细血管前括约肌肾上腺素能张力的变化。

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