对通过电刺激兔下丘脑获得的活跃肌肉血管舒张的嘌呤能成分的分析。
An analysis of the purinergic component of active muscle vasodilatation obtained by electrical stimulation of the hypothalamus in rabbits.
作者信息
Shimada S G, Stitt J T
出版信息
Br J Pharmacol. 1984 Oct;83(2):577-89. doi: 10.1111/j.1476-5381.1984.tb16522.x.
In anaesthetized rabbits, electrical stimulation of the hypothalamus in areas analogous to the defence area in cats produces the 'defence reaction.' This response includes signs of arousal and a large increase in blood flow to skeletal muscle in the hind limb caused by a vasodilatation in the skeletal muscle vasculature. The vasodilatation is a sympathetic response, and it is not dependent upon muscle activity in the hind limb. The muscle vasodilatation is insensitive to alpha-adrenoceptor, beta-adrenoceptor, cholinoceptor and histamine receptor antagonists. Intra-arterial injections of the purinoceptor agonists, adenosine triphosphate (ATP) and adenosine, mimic the vasodilatation produced by electrical stimulation. The P1-purinoceptor blocker, aminophylline, attenuates adenosine-induced vasodilatation, but it does not affect the vasodilatation produced by ATP or hypothalamic stimulation. The P2-purinoceptor blocker, antazoline, attenuates the vasodilatation produced by both ATP and hypothalamic stimulation. Our results suggest that the muscle vasodilatation produced by hypothalamic stimulation is mediated by purinergic nerves which release ATP and act on P2-purinoceptors.
在麻醉的兔子中，电刺激下丘脑与猫的防御区类似的区域会产生“防御反应”。这种反应包括觉醒迹象以及后肢骨骼肌血流量大幅增加，这是由骨骼肌血管舒张引起的。血管舒张是一种交感反应，且不依赖于后肢的肌肉活动。肌肉血管舒张对α - 肾上腺素能受体、β - 肾上腺素能受体、胆碱能受体和组胺受体拮抗剂不敏感。动脉内注射嘌呤受体激动剂三磷酸腺苷（ATP）和腺苷可模拟电刺激产生的血管舒张。P1嘌呤受体阻滞剂氨茶碱可减弱腺苷诱导的血管舒张，但不影响ATP或下丘脑刺激产生的血管舒张。P2嘌呤受体阻滞剂安他唑啉可减弱ATP和下丘脑刺激产生的血管舒张。我们的结果表明，下丘脑刺激产生的肌肉血管舒张是由释放ATP并作用于P2嘌呤受体的嘌呤能神经介导的。
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