Das D K, Neogi A
Clin Physiol Biochem. 1984;2(1):32-8.
Oxygen-derived free radicals have been shown to alter endothelial cell functions in lung. Enzymatically generated superoxide anions inactivated (Na + K)ATPase activity and caused lipid peroxidation in lung. Superoxide dismutase or allopurinol, but not ATP, protected this oxy radical-mediated depression of ATPase activity.
氧衍生的自由基已被证明会改变肺内皮细胞的功能。酶促产生的超氧阴离子会使(钠+钾)ATP酶失活,并导致肺组织发生脂质过氧化。超氧化物歧化酶或别嘌呤醇(而非ATP)可保护这种氧自由基介导的ATP酶活性降低。