Kujath P, Bruch H P, Schmidt E, Döll W
Chirurg. 1984 Aug;55(8):519-22.
The effects of perioperative antibiotic prophylaxis in elective colon surgery was evaluated in a prospective study on 100 patients. Bowel cleansing was done by orthograde lavage. The patients were divided into 5 groups receiving equally cefotaxime 3 x 2 g, lamoxactam 3 x 2 g, cefmenoxime 3 x 1 g, mezlocillin 3 x 5 g an piperacillin 3 x 4 g. Mucosa biopsies of the resected colon were taken for aerobic and anaerobic cultures. Further mucosal serum probes were frozen immediately for determination of tissue and serum levels of the antibiotics. Our results show that bacterial growth of the colon mucosa was significantly reduced. Anaerobes were identified in only 8%. The tissue concentrations exceeded the MIC-levels of the identified bowel organisms many times over. The clinical infection rate was 4%. All administered antibiotics can be recommended without reservation.
在一项针对100例患者的前瞻性研究中，评估了围手术期抗生素预防在择期结肠手术中的效果。通过顺行灌洗进行肠道清洁。患者被分为5组，分别接受等量的头孢噻肟（3×2克）、拉氧头孢（3×2克）、头孢甲肟（3×1克）、美洛西林（3×5克）和哌拉西林（3×4克）。对切除结肠的黏膜进行活检，用于需氧和厌氧培养。另外，立即冷冻黏膜血清样本，以测定抗生素的组织和血清水平。我们的结果表明，结肠黏膜的细菌生长显著减少。仅8%的样本中鉴定出厌氧菌。组织浓度超过所鉴定肠道微生物的最低抑菌浓度水平许多倍。临床感染率为4%。所有使用的抗生素均可毫无保留地推荐。
