Eikenburg D C
Eur J Pharmacol. 1984 Oct 1;105(1-2):161-5. doi: 10.1016/0014-2999(84)90661-7.
Pressor responses to periarterial nerve stimulation in the in situ perfused mesentery were potentiated by rauwolscine while responses to norepinephrine and phenylephrine were unaffected. Pressor responses to nerve stimulation, norepinephrine and phenylephrine were abolished by prazosin. No responses could be elicited in the mesentery by tramazoline. Thus, pressor responses to nerve stimulation and norepinephrine in this vascular bed are mediated by alpha 1-adrenoceptors while prejunctional alpha 2-adrenoceptors exert a negative feedback influence on vascular neurotransmission.
在原位灌注的肠系膜中，萝芙辛增强了对动脉周围神经刺激的升压反应，而对去甲肾上腺素和去氧肾上腺素的反应未受影响。哌唑嗪消除了对神经刺激、去甲肾上腺素和去氧肾上腺素的升压反应。曲马唑啉在肠系膜中未引发任何反应。因此，该血管床中对神经刺激和去甲肾上腺素的升压反应由α1肾上腺素能受体介导，而突触前α2肾上腺素能受体对血管神经传递发挥负反馈作用。
