辐射诱导胸腺嘧啶-胸腺嘧啶交联的形成。
Radiation-induced formation of thymine-thymine crosslinks.
作者信息
Dizdaroglu M, Simic M G
出版信息
Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Sep;46(3):241-6. doi: 10.1080/09553008414551361.
PMID:6092292
Abstract
The formation of dimers upon gamma-irradiation of thymine, thymidine and thymidine-5'-monophosphate in N2O-saturated aqueous solution is reported. A method using capillary gas chromatography-mass spectrometry was developed for their separation and identification. Quantitative measurements reveal that about 50 per cent of OH adduct radicals of thymine undergo dimerization.
摘要
据报道，在N₂O饱和水溶液中，胸腺嘧啶、胸腺嘧啶核苷和胸腺嘧啶核苷 - 5'-单磷酸经γ辐射后会形成二聚体。开发了一种使用毛细管气相色谱 - 质谱联用的方法对其进行分离和鉴定。定量测量结果表明，胸腺嘧啶的OH加合物自由基约有50%会发生二聚化。
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