Craig J B, Jackson D V, Moody D, Cruz J M, Pope E K, Powell B L, Spurr C L, Capizzi R L
J Clin Oncol. 1984 Oct;2(10):1151-6. doi: 10.1200/JCO.1984.2.10.1151.
Computed cranial tomographic scans were performed as part of the pretreatment evaluation and at six- to nine-month intervals posttreatment in 13 patients with small cell lung carcinoma. All patients received 3,000 rad of prophylactic cranial irradiation delivered over two weeks in ten treatment fractions in conjunction with multiagent chemotherapy. Posttreatment scans documented an extraordinarily high frequency of abnormalities including cerebral atrophy (100%), ventricular dilatation (70%), and decreased coefficient of absorption in the white matter (15%). Unexplained neurologic abnormalities developed in four of six patients living at least 15 months after institution of therapy. As the number of long-term survivors of this type of lung cancer increases, the need for prospective comprehensive neuropsychologic assessment to determine the clinical significance of these changes is needed.
对13例小细胞肺癌患者进行了头颅计算机断层扫描，作为治疗前评估的一部分，并在治疗后每隔6至9个月进行一次扫描。所有患者在接受多药化疗的同时，在两周内分10次给予3000拉德的预防性颅脑照射。治疗后的扫描显示异常频率极高，包括脑萎缩（100%）、脑室扩张（70%）和白质吸收系数降低（15%）。在治疗开始后至少存活15个月的6例患者中，有4例出现了不明原因的神经异常。随着这类肺癌长期存活者数量的增加，需要进行前瞻性综合神经心理学评估，以确定这些变化的临床意义。
