Bertino J S, Reed M D, Halpin T C
JPEN J Parenter Enteral Nutr. 1984 Sep-Oct;8(5):556-9. doi: 10.1177/0148607184008005556.
The safety and efficacy of parenteral cholecalciferol was evaluated in the treatment and prevention of childhood rickets. Children with active disease, and those at high risk for developing rickets were treated either with intravenous or intramuscular cholecalciferol in dosages of 1000 to 1500 IU daily, for periods of 28 to 450 days. All children with rickets responded with radiographic evidence of healing. No child in the prophylaxis group developed bone disease. Side effects were minimal. Parenteral cholecalciferol is a safe and effective therapy for the treatment and prevention of childhood rickets.
评估了肠外胆钙化醇在治疗和预防儿童佝偻病方面的安全性和有效性。患有活动性疾病以及有患佝偻病高风险的儿童，接受了每日剂量为1000至1500国际单位的静脉或肌肉注射胆钙化醇治疗，疗程为28至450天。所有佝偻病患儿均有影像学愈合证据。预防组中没有儿童患骨病。副作用极小。肠外胆钙化醇是治疗和预防儿童佝偻病的一种安全有效的疗法。
