Karakiulakis G, Thomas P J, Papaioannidou P G, Paradelis A G
Methods Find Exp Clin Pharmacol. 1984 Aug;6(8):437-43.
Kinetic analysis of cGMP phosphodiesterase activity in the rat brain indicated that Km values did not differ significantly with sex, age (1 to 270 days old), or brain area (amygdala, cerebellum, cerebral cortex, hypothalamus, thalamus, reticular formation). There was no dimorphism in enzyme activity between normal or artificially mimicked gender, nor was there any significant variation in activity following short or long term alterations of endogenous levels of gonadal hormones in any of the brain regions investigated. Highest activity was observed in cerebral cortex and amygdala. Maturation caused a significant increase in enzyme activity, the adult levels being reached by the 38th to 40th day of life.
对大鼠大脑中cGMP磷酸二酯酶活性的动力学分析表明，米氏常数（Km值）在性别、年龄（1至270日龄）或脑区（杏仁核、小脑、大脑皮层、下丘脑、丘脑、网状结构）方面并无显著差异。在正常或人工模拟的性别之间，酶活性没有二态性，在所研究的任何脑区中，性腺激素内源性水平的短期或长期改变后，活性也没有任何显著变化。在大脑皮层和杏仁核中观察到最高活性。成熟导致酶活性显著增加，在出生后第38至40天达到成年水平。
