Yonemura U, Konishi K, Miazaki I, Miwa K
Nihon Geka Gakkai Zasshi. 1984 Aug;85(8):811-9.
Morphological and immunocytochemical studies of pancreatic material from a patient with multiple endocrine neoplasia type-1 revealed hyperplasia of islets, multiple microadenomas, adenomas and cancers. Cellular composition of the hyperplastic islets was almost normal but the enlargement of the size and increase of the numbers were observed. Furthermore, neoformation of islets from ducts were found here and there. These hyperplastic islets, microadenomas, adenomas and cancers merged into each other and some of these microadenomas demonstrated malignant pictures. Most of the microadenomas produced multiple peptide hormones, on the other hand some of these revealed a single hormonal activity. These results show that the abnormality of the primordial cells of the pancreatic endocrine cells develops these lesion.
对一名1型多发性内分泌腺瘤患者的胰腺组织进行的形态学和免疫细胞化学研究显示，胰岛增生、多发微腺瘤、腺瘤和癌。增生性胰岛的细胞组成基本正常，但观察到大小增大和数量增加。此外，还多处发现由导管形成的胰岛新生物。这些增生性胰岛、微腺瘤、腺瘤和癌相互融合，其中一些微腺瘤呈现恶性表现。大多数微腺瘤产生多种肽类激素，另一方面，其中一些显示单一激素活性。这些结果表明，胰腺内分泌细胞原始细胞的异常导致了这些病变。
