Molnár P, Hegedüs K
Surg Neurol. 1984 Nov;22(5):455-60. doi: 10.1016/0090-3019(84)90302-1.
Concurrent neoplastic transformation of different cellular elements resulting in an intraventricular and intraparenchymal tumor is described. An infiltrating astrocytoma of the left frontal lobe had been partially removed from a 43-yr-old woman. Four months later she died, and the autopsy revealed a recurrent astrocytoma and a closely apposed large intraventricular ependymoma. Both light microscopy and ultrastructural findings established the different nature of the two tumors. Theoretically they could represent collision or composite tumors. Another possibility would be that a relatively longstanding ependymoma induced the astrocytic neoplasm. The clinical history and the sequential morphological analysis, i.e., biopsy and autopsy sampling suggest that the ependymoma developed due to the inductive influence of the astrocytic growth.
描述了不同细胞成分同时发生肿瘤转化导致脑室内和脑实质内肿瘤的情况。一名43岁女性的左额叶浸润性星形细胞瘤已被部分切除。四个月后她死亡，尸检发现复发性星形细胞瘤和紧密相邻的一个大的脑室内室管膜瘤。光学显微镜和超微结构检查结果均证实了这两种肿瘤的不同性质。理论上它们可能代表碰撞瘤或复合瘤。另一种可能性是，一个存在时间相对较长的室管膜瘤诱发了星形细胞瘤。临床病史及连续的形态学分析，即活检和尸检取样表明，室管膜瘤是由于星形细胞生长的诱导作用而发生的。
