Lönnqvist B, Ringdén O, Wahren B, Gahrton G, Lundgren G
Transplantation. 1984 Nov;38(5):465-8. doi: 10.1097/00007890-198411000-00004.
Of 68 consecutive allogeneic bone marrow transplant patients, 53 survived more than three months after transplantation. Twenty-two (42%) developed chronic graft-versus-host disease (GVHD). Chronic GVHD was more common among patients who had previously experienced cytomegalovirus (CMV) infection (20/36, 56%) than among those without signs of active CMV infection (2/17, 12%) (P less than 0.01). The CMV infections preceded the development of chronic GVHD by a median of 128 days (range 23-322 days). Children below 14 years of age who had had CMV infection developed chronic GVHD as often as older patients (8/14 vs. 12/22). CMV infection may pave the way for chronic GVHD.
在68例连续接受异基因骨髓移植的患者中，53例在移植后存活超过3个月。22例（42%）发生了慢性移植物抗宿主病（GVHD）。慢性GVHD在先前经历过巨细胞病毒（CMV）感染的患者中更为常见（20/36，56%），而在没有活动性CMV感染迹象的患者中则较少见（2/17，12%）（P<0.01）。CMV感染先于慢性GVHD发生，中位时间为128天（范围23 - 322天）。14岁以下曾感染CMV的儿童发生慢性GVHD的频率与年长患者相同（8/14 vs. 12/22）。CMV感染可能为慢性GVHD的发生铺平道路。
