[Characteristics of enterovirus infection in cultures of human and mouse hybrid cells].

Lines of human-mouse hybrid cells susceptible to infection with poliomyelitis types I, II, III, ECHO type 1 and 12, and Coxsackie A7 viruses have been derived. The presence in the hybrid cells of 2 and 3 genomes of the nonpermissive cell partner (mouse) was shown not to inhibit enterovirus reproduction. Hybrid cultures differed in their sensitivity to the mutagenic action of poliomyelitis virus. There was no correlation between poliomyelitis virus yield and the number of chromosome breaks in hybrid cells. Poliomyelitis virus type I-infected hybrid cultures passaged for 11/2 months eliminated this virus and subsequently became less sensitive to reinfection with poliomyelitis virus of all 3 types but retained their original sensitivity to Coxsackie and ECHO viruses.