Kurtz A, Pfeilschifter J, Bauer C
Biochem Biophys Res Commun. 1984 Oct 30;124(2):359-66. doi: 10.1016/0006-291x(84)91561-4.
Using cell cultures rich in renal juxtaglomerular cells we found that a change of the intracellular c-AMP concentration is not a prerequisite for an alteration of the renin secretion rate. Modulators of renin secretion including activators of the adenylate cyclase, however, altered the calcium permeability of the cellular plasma membrane in a way that stimulators of renin secretion lowered the calcium permeability and vice versa. Our results suggest that renin secretion is controlled by the intracellular calcium concentration and not by c-AMP. We postulate that modulators of renin secretion act by changing the calcium permeability of the cell membrane.
利用富含肾近球细胞的细胞培养物，我们发现细胞内c-AMP浓度的变化并非肾素分泌率改变的先决条件。然而，包括腺苷酸环化酶激活剂在内的肾素分泌调节剂，以一种肾素分泌刺激剂降低钙通透性、反之亦然的方式，改变了细胞质膜的钙通透性。我们的结果表明，肾素分泌受细胞内钙浓度而非c-AMP的控制。我们推测，肾素分泌调节剂通过改变细胞膜的钙通透性发挥作用。
