[甲状腺激素在特定受体上结合位点的构型与特性]
[Configuration and properties of a binding site for thyroid hormones on a specific receptor].
作者信息
Tropsha A E, Rakhmaninova A B, Iaguzhinskiĭ L S
出版信息
Bioorg Khim. 1984 Apr;10(4):483-92.
PMID:6093814
Abstract
An analysis has been carried out of data available in literature on structure-function relationships for thyroid hormones, namely thyroxine, triiodothyronine and their analogues. The configuration and dimensions of the hormone-binding site of the receptor in a hormone-receptor complex are described. The receptor is shown to have a strained conformation in the complex. The analysis is indicative of the existence of two types of hormone-receptor complexes, a particular type being determined by the dimensions of analogues.
摘要
已对文献中有关甲状腺激素（即甲状腺素、三碘甲状腺原氨酸及其类似物）结构-功能关系的现有数据进行了分析。描述了激素-受体复合物中受体激素结合位点的构型和尺寸。结果表明该受体在复合物中具有应变构象。该分析表明存在两种类型的激素-受体复合物，一种特定类型由类似物的尺寸决定。
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