充血性心力衰竭时血浆环核苷酸浓度升高。
Increased plasma cyclic nucleotide concentrations in congestive heart failure.
作者信息
Ogawa K, Shiozu H, Mizuno K, Ban M, Ito T, Satake T
出版信息
Br Heart J. 1984 Nov;52(5):524-9. doi: 10.1136/hrt.52.5.524.
Plasma concentrations of cyclic nucleotides (adenosine monophosphate (AMP) and guanosine monophosphate (GMP) were measured by an ultrasensitive radioimmunoassay in 138 patients with heart failure due to various causes. Measurements were related to the New York Heart Association classification of symptoms, plasma noradrenaline concentrations, and mean pulmonary artery pressures. Serial concentrations of cyclic AMP and GMP were also measured daily in four patients treated for acute left ventricular failure. Plasma concentrations of cycle AMP were related to the severity of the heart failure, plasma noradrenaline concentrations, and pulmonary artery pressures. Cyclic AMP concentrations fell rapidly after treatment of acute left ventricular failure. Plasma concentrations of cyclic GMP also depended on the severity of heart failure and the pulmonary artery pressure, and decreased sharply with treatment although remaining at a high value. The cyclic GMP concentrations were significantly higher in patients with mitral stenosis than in those with other types of heart failure.
采用超灵敏放射免疫分析法测定了138例各种病因所致心力衰竭患者血浆环核苷酸（腺苷一磷酸（AMP）和鸟苷一磷酸（GMP））的浓度。这些测量结果与纽约心脏协会症状分级、血浆去甲肾上腺素浓度及平均肺动脉压相关。还对4例急性左心室衰竭患者进行了每日循环AMP和GMP浓度的连续测定。血浆环AMP浓度与心力衰竭的严重程度、血浆去甲肾上腺素浓度及肺动脉压相关。急性左心室衰竭治疗后，环AMP浓度迅速下降。血浆环GMP浓度也取决于心力衰竭的严重程度和肺动脉压，治疗后虽仍处于较高水平但急剧下降。二尖瓣狭窄患者的环GMP浓度显著高于其他类型心力衰竭患者。
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