Landini M P, Baldassarri B
Diagn Immunol. 1983;1(4):284-7.
Due to the emergence of drug-resistant mutants during the treatment of viral infections, an easy and rapid laboratory technique to assay the antiviral sensitivity of virus isolates could be extremely useful. In this brief report we describe the use of enzyme-linked immunoassay (EIA) to detect the susceptibility of herpes simplex virus (HSV) type 1 to three well known antiviral agents: Cytosine-arabinoside (Ara-C), 5'-iododeoxyuridine (IUDR), and acyclovir (ACG). The results indicate that EIA can easily give an accurate indication of antiviral susceptibility 24 hr after the isolation of the virus and provides important information from the therapeutical point of view.
由于在病毒感染治疗过程中会出现耐药突变体，因此一种简单快速的实验室技术来测定病毒分离株的抗病毒敏感性可能极其有用。在本简要报告中，我们描述了使用酶联免疫吸附测定法（EIA）来检测1型单纯疱疹病毒（HSV）对三种知名抗病毒药物的敏感性：阿糖胞苷（Ara-C）、5'-碘脱氧尿苷（IUDR）和阿昔洛韦（ACG）。结果表明，EIA能够在病毒分离后24小时轻松准确地指示抗病毒敏感性，并从治疗角度提供重要信息。
