Bakos P, Ponec J, Lichardus B
Gen Physiol Biophys. 1984 Aug;3(4):297-305.
The synthetic analogue of vasopressin, 1-deamino-8-D-arginine-vasopressin (dDAVP), possesses a protracted antidiuretic activity while having practically no pressoric activity as compared to arginine-vasopressin (AVP) or lysine-vasopressin (LVP). The effects of LVP and dDAVP were studied on the frog skin (Rana temporaria) sodium transport as reflected by the short-circuit current (SCC) level, on an Ussing apparatus. The application two different equimolar doses of LVP or dDAVP (approx. 9.4 X 10(-8) mol X l-1 and 18.8 X 10(-8) mol X l-1 to the inner surface of the skin resulted in identical maximal increases of sodium transport. However, the maximum transport stimulation after the application of dDAVP was delayed by about 30 min as compared to the stimulation by LVP (P less than 0.01). In addition, a protracted recovery of SCC towards its original levels was observed in experiments with dDAVP application after the hormone removal (P less than 0.01). It is concluded that dDAVP stimulates Na+ transport through the frog skin despite its lacking pressoric activity. Thus, the natriferic activity of vasopressin is related to its antidiuretic rather than pressoric activity. Maximum increase in the sodium transport following dDAVP application was delayed and more protracted as compared to the effect of LVP.
血管加压素的合成类似物1-去氨基-8-D-精氨酸血管加压素（dDAVP）具有持久的抗利尿活性，而与精氨酸血管加压素（AVP）或赖氨酸血管加压素（LVP）相比，其几乎没有升压活性。在Ussing装置上，通过短路电流（SCC）水平反映，研究了LVP和dDAVP对蛙皮（林蛙）钠转运的影响。将两种不同等摩尔剂量的LVP或dDAVP（约9.4×10⁻⁸mol·L⁻¹和18.8×10⁻⁸mol·L⁻¹）应用于皮肤内表面，导致钠转运的最大增加相同。然而，与LVP刺激相比，应用dDAVP后的最大转运刺激延迟了约30分钟（P<0.01）。此外，在去除激素后应用dDAVP的实验中，观察到SCC向其原始水平的持久恢复（P<0.01）。结论是，尽管dDAVP缺乏升压活性，但它仍能刺激蛙皮的Na⁺转运。因此，血管加压素的排钠活性与其抗利尿活性而非升压活性有关。与LVP的作用相比，应用dDAVP后钠转运的最大增加延迟且更持久。
