Crooks J, White L O, Burville L J, Speidel B D, Reeves D S
J Antimicrob Chemother. 1984 Sep;14 Suppl B:97-101. doi: 10.1093/jac/14.suppl_b.97.
Cefotaxime was given to neonates as treatment of infection in a dose of 25 mg/kg 12 hourly by intravenous injection. Blood samples taken by heel-prick were specially treated to minimize any effect of haemolysis on the hydrolysis of cefotaxime. The mean peak plasma concentrations of cefotaxime on the first, second and third days of therapy were 43, 40 and 52 mg/l, respectively, with mean plasma half lives of 4.0, 2.7 and 3.2 h. The mean peak concentrations of desacetyl-cefotaxime were about a quarter of those of cefotaxime, which is in good agreement with adult studies, but much lower than those previously published in studies with neonates. These results emphasize the care that is necessary in the assay of body fluids and tissues for cefotaxime and desacetyl-cefotaxime if accurate results are to be obtained.
头孢噻肟以25毫克/千克的剂量，每12小时静脉注射一次，用于治疗新生儿感染。通过足跟采血采集的血样经过特殊处理，以尽量减少溶血对头孢噻肟水解的任何影响。治疗第一天、第二天和第三天头孢噻肟的平均血浆峰值浓度分别为43毫克/升、40毫克/升和52毫克/升，平均血浆半衰期分别为4.0小时、2.7小时和3.2小时。去乙酰头孢噻肟的平均峰值浓度约为头孢噻肟的四分之一，这与成人研究结果相符，但远低于之前新生儿研究中公布的浓度。这些结果强调，如果要获得准确结果，在检测体液和组织中的头孢噻肟和去乙酰头孢噻肟时必须格外小心。
