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大肠杆菌青霉素结合蛋白5和6同时释放青霉噻唑酸和苯乙酰甘氨酸。

Simultaneous release of penicilloic acid and phenylacetyl glycine by penicillin-binding proteins 5 and 6 of Escherichia coli.

作者信息

Amanuma H, Strominger J L

出版信息

J Bacteriol. 1984 Nov;160(2):822-3. doi: 10.1128/jb.160.2.822-823.1984.

DOI:10.1128/jb.160.2.822-823.1984
PMID:6094494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC214817/
Abstract

Penicillin-binding proteins (PBPs) 5 and 6 of Escherichia coli released the bound penicilloyl moiety at an intermediate rate relative to, e.g., Staphylococcus aureus PBPs 4 (rapid) and 1 or 2 (slow). Each of these E. coli PBPs released the bound penicilloyl moiety as both penicilloic acid (hydrolysis) and phenylacetyl glycine (scission of the C-5--C-6 bond followed by hydrolysis).

摘要

大肠杆菌的青霉素结合蛋白（PBPs）5和6释放结合的青霉噻唑基团的速率处于中间水平，相对于例如金黄色葡萄球菌的PBPs 4（快速）和1或2（缓慢）而言。这些大肠杆菌PBPs中的每一个都以青霉酸（水解）和苯乙酰甘氨酸（C-5-C-6键断裂后水解）的形式释放结合的青霉噻唑基团。

相似文献

1
Simultaneous release of penicilloic acid and phenylacetyl glycine by penicillin-binding proteins 5 and 6 of Escherichia coli.大肠杆菌青霉素结合蛋白5和6同时释放青霉噻唑酸和苯乙酰甘氨酸。
J Bacteriol. 1984 Nov;160(2):822-3. doi: 10.1128/jb.160.2.822-823.1984.
2
Affinity of temocillin for Escherichia coli K-12 penicillin-binding proteins.替莫西林对大肠杆菌K-12青霉素结合蛋白的亲和力。
Antimicrob Agents Chemother. 1984 Sep;26(3):335-8. doi: 10.1128/AAC.26.3.335.
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[Relation between PBPs (penicillin-binding proteins) and growth curves of Escherichia coli submitted to ampicillin and oxacillin].
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引用本文的文献

1
Penicillin-binding site on the Escherichia coli cell envelope.大肠杆菌细胞膜上的青霉素结合位点。
J Bacteriol. 1986 Aug;167(2):492-5. doi: 10.1128/jb.167.2.492-495.1986.

本文引用的文献

1
Purification and properties of penicillin-binding proteins 5 and 6 from Escherichia coli membranes.大肠杆菌膜中青霉素结合蛋白5和6的纯化及特性
J Biol Chem. 1980 Dec 10;255(23):11173-80.
2
Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics.青霉素结合蛋白与β-内酰胺类抗生素的作用机制
Annu Rev Biochem. 1983;52:825-69. doi: 10.1146/annurev.bi.52.070183.004141.
3
Fragmentation of benzylpenicillin after interaction with the exocellular DD-carboxypeptidase-transpeptidases of Streptomyces R61 and R39.与链霉菌R61和R39的胞外DD-羧肽酶-转肽酶相互作用后苄青霉素的碎片化
Nature. 1975 Nov 13;258(5531):168-70. doi: 10.1038/258168a0.
4
Degradation of penicillin G to phenylacetylglycine by D-alanine carboxypeptidase from Bacillus stearothermophilus.嗜热脂肪芽孢杆菌的D-丙氨酸羧肽酶将青霉素G降解为苯乙酰甘氨酸。
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3463-7. doi: 10.1073/pnas.72.9.3463.
5
Formation of 5,5-dimethyl-delta2-thiazoline-4-carboxylic acid during cleavage of penicillin G by D-alanine carboxypeptidase from Bacillus stearothermophilus.
J Biol Chem. 1976 Dec 25;251(24):7947-9.
6
Stability of D-5,5-dimethyl-delta2-thiazoline-4-carboxylic acid in relation to its possible occurrence as a degradation product of penicillin by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 and the membrane-bound dd-carboxypeptidase from Bacillus stearothermophilus.D-5,5-二甲基-δ2-噻唑啉-4-羧酸的稳定性，这涉及到它作为青霉素降解产物可能的产生情况，该降解由来自链霉菌R61的胞外DD-羧肽酶-转肽酶以及来自嗜热脂肪芽孢杆菌的膜结合dd-羧肽酶引发。
J Biol Chem. 1978 May 25;253(10):3660-5.
7
A membrane enzyme from Staphylococcus aureus which catalyzes transpeptidase, carboxypeptidase, and penicillinase activities.一种来自金黄色葡萄球菌的膜酶，可催化转肽酶、羧肽酶和青霉素酶活性。
J Biol Chem. 1978 Feb 25;253(4):1272-8.