Wedderburn N, Edwards J M, Desgranges C, Fontaine C, Cohen B, de Thé G
J Infect Dis. 1984 Dec;150(6):878-82. doi: 10.1093/infdis/150.6.878.
Callithrix jacchus marmosets infected with Epstein-Barr virus (EBV) with or without concurrent treatment with cyclosporin A (CySA) remained healthy. Five marmosets given virus alone developed lymphocytosis and heterophile antibody. Antibody to EBV capsid antigens (VCA) appeared and remained at titers of 1:40-1:80 from 15 weeks onward. Two animals produced antibody to the R component of early antigens (EA) from six weeks onward. Five CySA-treated EBV-infected marmosets showed no increase in total lymphocyte counts; only two developed heterophile antibody. Four developed persistent antibody to the EA-R component. All developed antibody to VCA, and mean titers were higher than in animals given EBV alone. Antibody to VCA also appeared in animals given EBV into Waldeyer's ring. Because these responses to EBV resemble those of humans, C. jacchus may provide a useful model for exploring the potential of cofactors in inducing EBV-associated malignancy.
感染爱泼斯坦-巴尔病毒（EBV）的普通狨猴，无论是否同时接受环孢素A（CySA）治疗，均保持健康。仅接种病毒的5只狨猴出现淋巴细胞增多和嗜异性抗体。EBV衣壳抗原（VCA）抗体出现，并从第15周起维持在1:40 - 1:80的滴度。2只动物从第6周起产生早期抗原（EA）R成分的抗体。5只接受CySA治疗的EBV感染狨猴的总淋巴细胞计数没有增加；只有2只产生了嗜异性抗体。4只产生了针对EA - R成分的持续抗体。所有动物均产生了VCA抗体，且平均滴度高于仅接种EBV的动物。将EBV接种到瓦尔代尔环的动物也出现了VCA抗体。由于这些对EBV的反应与人类相似，普通狨猴可能为探索辅助因子在诱导EBV相关恶性肿瘤中的作用提供一个有用的模型。
