Miyazaki N, Kajiki A, Yamazaki H, Harada S, Kido M, Kuroiwa A
Jpn J Antibiot. 1984 Oct;37(10):1763-5.
Single doses of cefmenoxime (CMX), 1 g intravenous drip infusion, were administrated to 5 patients with pleural effusion. The study group consisted of 3 men and 2 women, aged 38 to 69 years (mean 54.8 years); 4 had carcinoma with pleural effusion and 1 had SLE. Pleural fluid and serum samples were taken at intervals 1 to 24 hours for determination of CMX levels. The following results were obtained: Intravenous drip infusion of 1 g CMX yielded a peak pleural concentration of 4.5 micrograms/ml after 2 hours and pleural levels over 3 micrograms/ml were maintained for 5.5 hours after intravenous drip administration. Ratio maximum pleural concentration to peak serum level reached 15.0 +/- 8.3% at 2 hours after intravenous drip administration.
对5例胸腔积液患者静脉滴注单剂量1g头孢甲肟（CMX）。研究组包括3名男性和2名女性，年龄38至69岁（平均54.8岁）；4例为癌性胸腔积液，1例为系统性红斑狼疮（SLE）。在1至24小时内间隔采集胸水和血清样本以测定CMX水平。结果如下：静脉滴注1g CMX后2小时胸腔峰值浓度为4.5微克/毫升，静脉滴注后胸膜水平超过3微克/毫升维持5.5小时。静脉滴注后2小时胸腔最大浓度与血清峰值水平之比达到15.0±8.3%。
