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儿茶酚胺处理的豚鼠浦肯野纤维中乙酰胆碱去除后缓慢内向电流的短暂增加。

Transient increase in the slow inward current following acetylcholine removal in catecholamine-treated guinea-pig Purkinje fibers.

作者信息

Ehara T, Mitsuiye T

出版信息

Jpn J Physiol. 1984;34(4):775-9. doi: 10.2170/jjphysiol.34.775.

DOI:10.2170/jjphysiol.34.775
PMID:6094896
Abstract

In voltage-clamped guinea-pig Purkinje fibers, removal of acetylcholine (ACh) in the presence of isoproterenol produced a rebound increase in the slow inward current. This effect of ACh was abolished by atropine. These results are consistent with the hypothesis that cessation of the stimulation of myocardial muscarinic receptors transiently leads to enhanced activity of the beta-receptor/slow channel system in this tissue.

摘要

在电压钳制的豚鼠浦肯野纤维中，在异丙肾上腺素存在的情况下去除乙酰胆碱（ACh）会导致缓慢内向电流出现反弹性增加。ACh的这种作用被阿托品消除。这些结果与以下假设一致：心肌毒蕈碱受体刺激的停止会短暂地导致该组织中β受体/慢通道系统的活性增强。

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Transient increase in the slow inward current following acetylcholine removal in catecholamine-treated guinea-pig Purkinje fibers.儿茶酚胺处理的豚鼠浦肯野纤维中乙酰胆碱去除后缓慢内向电流的短暂增加。
Jpn J Physiol. 1984;34(4):775-9. doi: 10.2170/jjphysiol.34.775.
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J Physiol. 2000 Jul 1;526 Pt 1(Pt 1):57-68. doi: 10.1111/j.1469-7793.2000.t01-1-00057.x.
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Nitric oxide signaling mediates stimulation of L-type Ca2+ current elicited by withdrawal of acetylcholine in cat atrial myocytes.一氧化氮信号传导介导了猫心房肌细胞中乙酰胆碱撤除所引发的L型钙电流刺激。
J Gen Physiol. 1998 Jan;111(1):113-25. doi: 10.1085/jgp.111.1.113.