[光感受器膜中的环磷酸鸟苷结合中心]
[cGMP-binding centers in photoreceptor membranes].
作者信息
Volotovskiĭ I D, Baranova L A, Sheĭko L M, Levko A V, Konev S V
出版信息
Mol Biol (Mosk). 1984 Jul-Aug;18(4):1053-9.
The binding of cGMP by structural components of bovine rod outer segments was studied. The discs and plasma membranes were shown to contain two types of the specific binding sites for cGMP which are distinct from cyclic GMP phosphodiesterase. The sites have a "high" and "low" (Kd = 0.1 divided by 0.35 and 1.5 divided by 2.0 X 10(-6) M respectively) affinity for cGMP. They belong to membraneous integral proteins presumably associated with phospholipids. Their affinity for cGMP is controlled by GTP and calmodulin.
对牛视杆细胞外段结构成分与环磷酸鸟苷（cGMP）的结合进行了研究。结果表明，圆盘膜和质膜含有两种与环磷酸鸟苷特异性结合的位点，这两种位点与环磷酸鸟苷磷酸二酯酶不同。这些位点对cGMP具有“高”和“低”（解离常数Kd分别为0.1÷0.35和1.5÷2.0×10⁻⁶ M）亲和力。它们属于可能与磷脂相关的膜内在蛋白。它们对cGMP的亲和力受鸟苷三磷酸（GTP）和钙调蛋白控制。
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