Schechter A L, Stern D F, Vaidyanathan L, Decker S J, Drebin J A, Greene M I, Weinberg R A
Nature. 1984;312(5994):513-6. doi: 10.1038/312513a0.
A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.
一系列大鼠神经/胶质母细胞瘤都含有相同的转化基因（neu），该基因可诱导合成相对分子质量（Mr）为185,000的肿瘤抗原（p185）。neu癌基因与erb-B具有同源性，肿瘤抗原p185在血清学上与表皮生长因子（EGF）受体相关。两种蛋白质，即EGF受体和p185，似乎是不同的，因为它们共存于未转化的大鼠-1细胞中。
