腺病毒2型E1A产物可抑制增强子诱导的转录激活。
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription.
作者信息
Borrelli E, Hen R, Chambon P
出版信息
Nature. 1984;312(5995):608-12. doi: 10.1038/312608a0.
DOI:10.1038/312608a0
PMID:6095113
Abstract
The adenovirus-2 early region 1A (E1A) products repress activation of transcription induced by the simian virus 40, polyoma virus and adenovirus-2 E1A enhancers. The repression probably involves an interaction between the enhancer elements and a trans-acting factor(s), possibly the E1A products themselves.
摘要
腺病毒2型早期区域1A（E1A）产物可抑制由猿猴病毒40、多瘤病毒和腺病毒2型E1A增强子诱导的转录激活。这种抑制作用可能涉及增强子元件与反式作用因子之间的相互作用，可能反式作用因子就是E1A产物本身。
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