Pradhan S N
Neurosci Biobehav Rev. 1984 Fall;8(3):369-85. doi: 10.1016/0149-7634(84)90058-7.
DMHP (1-hydroxy-3-1', 2'-dimethylheptyl-6,6,9-trimethyl 7,8,9,10-tetrahydro-6-dibenzopyran or in brief dimethyl heptyl pyran, EA 1476) is a synthetic analog of delta 9-tetrahydrocannabinol (delta 9-THC). Both DMHP and its acetate, DMHPA (EA 2233) produce varying degrees of physical and mental incapacitation. Both compounds elicit orthostatic hypotension at dose levels far below those required to produce mild mental incapacitation. Compared with delta 9-THC, DMHP has clearly more potent and prolonged hypotensive action, but much less psychological effect. The potencies of DMHP and DMHPA are more or less similar, but the acetate derivative is more stable against the degrading effects of light and air. Like DMHP, DMHPA consists of eight isomers which vary in their potency. Accordingly, depending on the proportion of the isomers, the racemic mixtures show variability in their potencies. The isomers 2 and 4 have been shown to be more potent than the other isomers.
DMHP（1-羟基-3-（1'，2'-二甲基庚基）-6,6,9-三甲基-7,8,9,10-四氢-6H-二苯并吡喃，简称二甲基庚基吡喃，EA 1476）是δ9-四氢大麻酚（δ9-THC）的合成类似物。DMHP及其乙酸酯DMHPA（EA 2233）都会导致不同程度的身心机能丧失。这两种化合物在远低于导致轻度精神机能丧失所需剂量的水平下就会引发体位性低血压。与δ9-THC相比，DMHP具有明显更强且更持久的降压作用，但心理效应要小得多。DMHP和DMHPA的效力大致相似，但乙酸酯衍生物对光和空气的降解作用更稳定。与DMHP一样，DMHPA由八种异构体组成，其效力各不相同。因此，根据异构体的比例，外消旋混合物的效力会有所变化。已证明异构体2和4比其他异构体更有效。
