Chaieb L, Vidal-Trecan G, Laudat M H, Guilhaume B, Bertagna X, Bricaire H, Luton J P
Presse Med. 1984 Oct 13;13(36):2183-7.
The reliability of the beta 1-24 corticotropin test, which is both cheap and safe, in the assessment of the hypothalamic-pituitary-adrenocortical function was re-evaluated by comparing its results with those of the metyrapone test in 71 subjects: 30 controls and 51 patients with suspected pituitary-adrenal dysfunction. Response to a 500 micrograms intramuscular injection of beta 1-24 corticotropin was evaluated by measuring the 60 min plasma cortisol levels; 4.5 g of metyrapone divided into 6 doses were then administered orally and response was evaluated by measuring plasma 11-desoxycortisol levels. A highly significant correlation (r = 0.79; p less than 0.001) was observed between plasma cortisol and plasma 11-desoxycortisol levels. The results were best interpreted by expressing the values obtained as plasma cortisol concentrations which, in normal subjects are at least 21 micrograms/100 ml. The rapid beta 1-24 corticotropin test was found to be very reliable (sensitivity 90%, specificity 100%) to detect adrenal insufficiency, irrespective of the organs affected on the hypothalamic-adrenocortical axis.
通过将71名受试者（30名对照者和51名疑似垂体 - 肾上腺功能障碍患者）的β1 - 24促肾上腺皮质激素试验结果与甲吡酮试验结果进行比较，对既便宜又安全的β1 - 24促肾上腺皮质激素试验在评估下丘脑 - 垂体 - 肾上腺皮质功能方面的可靠性进行了重新评估。通过测量60分钟时的血浆皮质醇水平来评估肌肉注射500微克β1 - 24促肾上腺皮质激素后的反应；然后口服4.5克甲吡酮，分为6剂，并通过测量血浆11 - 脱氧皮质醇水平来评估反应。观察到血浆皮质醇水平与血浆11 - 脱氧皮质醇水平之间存在高度显著的相关性（r = 0.79；p < 0.001）。通过将获得的值表示为血浆皮质醇浓度来最好地解释结果，在正常受试者中，血浆皮质醇浓度至少为21微克/100毫升。发现快速β1 - 24促肾上腺皮质激素试验在检测肾上腺功能不全方面非常可靠（敏感性90%，特异性100%），无论下丘脑 - 肾上腺皮质轴上受影响的器官如何。
