Noël L, Messian O, Grand M, Lambotin B, Couroucé A M, Saint-Paul B
Rev Fr Transfus Immunohematol. 1984 Sep;27(4):537-41. doi: 10.1016/s0338-4535(84)80154-3.
212 male prisoners were collected at the prison in March 1983. Anti-HBc and HBs Ag were detected by a combined test (AUSRIA-CORE, Abbott Laboratories). 67 sera (31,5%) were anti-HBc positive, 7 of them HBs Ag positive. Screening for anti-HTLV (anti-p24) was negative for all the donors. Beta 2 microglobulin levels were determined on 115 sera (B2-micro RIA 100, Pharmacia Laboratories). 8 had levels above 2,6 mg/l (greater than 2 SD). These 8 sera were anti-HBc positive and one of them HBs Ag positive 3 HBs Ag positive donors had non elevated Beta 2 microglobulin levels. This survey confirms that prisoners as blood donors should be regarded as carrying a high risk of transmission of HBV and probably other infectious agents with similar epidemiology. The signification of elevated Beta 2 microglobulin levels deserves further investigations since this determination could be of value as an additive test to increase the safety of blood products.
1983年3月，在一所监狱收集了212名男性囚犯的样本。采用联合检测法（澳大利亚核心检测法，雅培实验室）检测抗-HBc和HBs Ag。67份血清（31.5%）抗-HBc呈阳性，其中7份HBs Ag呈阳性。所有献血者的抗-HTLV（抗-p24）筛查均为阴性。对115份血清测定了β2微球蛋白水平（B2-微球蛋白放射免疫分析试剂盒100，法玛西亚实验室）。8人的水平高于2.6 mg/l（大于2个标准差）。这8份血清抗-HBc呈阳性，其中1份HBs Ag呈阳性。3名HBs Ag呈阳性的献血者β2微球蛋白水平未升高。这项调查证实，应将囚犯献血者视为具有传播HBV以及可能传播其他具有相似流行病学特征的传染原的高风险人群。β2微球蛋白水平升高的意义值得进一步研究，因为这一检测可能作为一项附加检测，对提高血液制品安全性具有价值。
