Nishiyama R H, Thompson N W, Lloyd R, Augur N A
Surgery. 1984 Dec;96(6):1038-44.
Two patients with secretory diarrhea and signs and symptoms consistent with the Verner-Morrison syndrome and islet cell hyperplasia are described. Both patients responded well to subtotal pancreatectomies. The morphologic changes in the pancreata were characterized by proliferation of islets associated with periductal and interstitial fibrosis. Immunohistochemical stains demonstrated increased staining for serotonin in islet cells. A few islet cells also stained for vasoactive intestinal polypeptide. The significance of these results is discussed.
本文描述了两名患有分泌性腹泻且具有与韦尔纳-莫里森综合征及胰岛细胞增生相符的体征和症状的患者。两名患者均对胰腺次全切除术反应良好。胰腺的形态学改变特征为胰岛增生并伴有导管周围和间质纤维化。免疫组织化学染色显示胰岛细胞中血清素染色增加。少数胰岛细胞也显示血管活性肠肽染色阳性。文中讨论了这些结果的意义。
