Van der Hoek J C, Oranje A P, Huisman J, Choufoer-Habova J J, Veldboer J C, Versteegh F G, Van Joost T, Stolz E
Tijdschr Kindergeneeskd. 1984 Jun;52(3):82-8.
Five patients with hand-, foot- and mouth disease, caused by infection with Coxsackievirus type A16, are described in an epidemic outbreak of this disease. Hand-, foot- and mouth disease, is characterized by a most distinctive enanthem-exanthemcomplex. In 65% of the cases a vesiculopapular exanthem is noted. Most cases are described in epidemic outbreaks. Although the vast majority of occurrences of the disease have been due to Coxsackie A16 viral infections, occasionally Coxsackie A5, A10 and enterovirus 71, seldom Coxsackievirus B1 or B3, have been etiologically incriminated. In this article attention is paid to the clinical characteristics, the epidemiology and the differential diagnostic aspects of hand-, foot- and mouth disease.
本文描述了5例由A16型柯萨奇病毒感染引起的手足口病患者，此次为该病的一次流行爆发。手足口病的特征是一种极为独特的黏膜疹-皮疹综合征。65%的病例可见水疱丘疹性皮疹。大多数病例是在流行爆发中被描述的。尽管该疾病绝大多数病例是由A16型柯萨奇病毒感染所致，但偶尔也有A5型、A10型柯萨奇病毒及肠道病毒71型感染引起的报道，很少有由B1型或B3型柯萨奇病毒引起的病例。本文关注手足口病的临床特征、流行病学及鉴别诊断方面。
