Balázs M
Virchows Arch A Pathol Anat Histopathol. 1984;405(1):119-29. doi: 10.1007/BF00694930.
The electron microscopic features of cytomegalovirus hepatitis in the liver biopsy of a three-week-old infant were studied. The liver cells did not contain virus, but severe alterations similar to virus hepatitis were observed. In the bile duct cells, nuclear and cytoplasmic virus inclusions were demonstrated. In the nuclear inclusions virus particles of various degrees of maturity were embedded in dense granular material. The cytoplasm of the infected cells contained vacuoles with mature viruses. The Golgi zone seemed to play an important role in vacuole formation. In another type of infected cell, viruses were lying free in the cytoplasm and passed into the lumen of the bile ducts. It is concluded that viruses are eliminimated by the bile. Based on this electron microscopical observations, the examination of duodenal fluid is recommended as a new diagnostic procedure for demonstrating viruses.
对一名三周大婴儿肝脏活检中巨细胞病毒肝炎的电子显微镜特征进行了研究。肝细胞中未发现病毒，但观察到了类似于病毒性肝炎的严重改变。在胆管细胞中，发现了核内和胞质内病毒包涵体。在核内包涵体中，不同成熟度的病毒颗粒嵌入致密颗粒物质中。受感染细胞的细胞质中含有带有成熟病毒的空泡。高尔基体区域似乎在空泡形成中起重要作用。在另一种类型的受感染细胞中，病毒游离于细胞质中并进入胆管腔。得出的结论是病毒通过胆汁排出。基于这些电子显微镜观察结果，建议将十二指肠液检查作为一种新的诊断程序来检测病毒。
