位于人类δ-珠蛋白基因5'端3千碱基处的多态性Taq I限制性酶切位点与Gγ-和Aγ-珠蛋白基因内的多态性Hind III位点的非随机关联。
Non-random association of the polymorphic Taq I restriction site, located 3 KB 5' to the human delta-globin gene, with the polymorphic Hind III sites within the G gamma- and A gamma-globin genes.
作者信息
Poncet D, Salomé N, Kohen G, Godet J, Verdier G
出版信息
Acta Haematol. 1984;72(4):217-20. doi: 10.1159/000206393.
PMID:6095575
Abstract
During the study of the DNA from 25 beta-thalassemic subjects from mediterranean origin the polymorphic Taq I restriction site located 3-kb 5' to the human delta-globin gene, was found non-randomly associated to the polymorphic Hind III sites within the G gamma- and A gamma-globin genes. This indicates that the 3' limit of the linkage group of polymorphic restriction sites including the gamma-globin genes is located downstream to the polymorphic Taq I site.
摘要
在对25名地中海血统的β地中海贫血患者的DNA进行研究时，发现位于人类δ珠蛋白基因5'端上游3 kb处的多态性Taq I限制性酶切位点与Gγ和Aγ珠蛋白基因内的多态性Hind III位点存在非随机关联。这表明包括γ珠蛋白基因在内的多态性限制性酶切位点连锁群的3'边界位于多态性Taq I位点的下游。
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