β-内酰胺酶抑制剂对革兰氏阴性菌生长培养物中β-内酰胺酶的作用与其对分离出的β-内酰胺酶的作用之间的相关性。
Correlation of the effect of beta-lactamase inhibitors on the beta-lactamase in growing cultures of gram-negative bacteria with their effect on the isolated beta-lactamase.
作者信息
Easton C J, Knowles J R
出版信息
Antimicrob Agents Chemother. 1984 Sep;26(3):358-63. doi: 10.1128/AAC.26.3.358.
Abstract
The effectiveness of clavulanic acid, sulbactam, quinacillin sulfone, and the carbapenems MM13902 and MM4550 as inhibitors of TEM-2 beta-lactamase in growing cultures of gram-negative bacteria has been studied. Each of these beta-lactams inhibited the enzyme in intact cells, and the nature of the inhibition correlated with studies on the purified enzyme. The potency of these compounds as inhibitors of the beta-lactamase in vivo can be correlated with the amounts hydrolyzed by the purified enzyme under saturating conditions during the inhibition of the enzyme in vitro.
摘要
已对克拉维酸、舒巴坦、喹那西林砜以及碳青霉烯类药物MM13902和MM4550作为革兰氏阴性菌生长培养物中TEM-2β-内酰胺酶抑制剂的有效性进行了研究。这些β-内酰胺类药物中的每一种都能在完整细胞中抑制该酶，且抑制的性质与对纯化酶的研究相关。这些化合物作为体内β-内酰胺酶抑制剂的效力可与在体外抑制该酶期间，纯化酶在饱和条件下所水解的量相关联。
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