Serov V V, Kuzin M I, Zolotarevskiĭ V B, Zal'tsman I N, Kulakova A M
Arkh Patol. 1984;46(9):25-32.
Morphological and mammographic study of small (less than 1 cm) focal mammary gland lesions of 170 women revealed foci of typical epithelium proliferation of the ducts and lobules, fibrosing adenosis, small duct papillomas and fibroadenoma, intraductal and ductal carcinoma in situ, sometimes with small invasion foci, infiltrating carcinoma, infiltrating lobular carcinoma. Peculiarities of small focal lesion morphology determine the mammographic picture. Analysis of nodular shadows on the mammogram gives as a rule a possibility to differentiate between benign conditions (focal proliferation of the epithelium, fibroadenoma), early carcinoma (intraductal and lobular in situ, sometimes with small foci of invasion) and infiltrating carcinoma. Calcareous deposits in both benign lesions and carcinomas do not differ mammographically. Morphogenetic link was revealed between foci of epithelium proliferation (benign displasia), intraductal and lobular carcinoma in situ and infiltrating carcinoma. Among 65 cases of non-palpable carcinoma, 31 (47.7%) were classified as early carcinoma and 34 (52.3%) as infiltrating carcinoma with a relatively low histological degree of malignancy. In both groups a good postoperative survival was observed.
对170名女性乳腺小（小于1厘米）局灶性病变进行的形态学和乳腺钼靶研究显示，存在导管和小叶典型上皮增生灶、纤维囊性乳腺病、小导管乳头状瘤和纤维腺瘤、导管内原位癌和导管癌，有时伴有小浸润灶、浸润性癌、浸润性小叶癌。小局灶性病变形态学特点决定了乳腺钼靶图像。乳腺钼靶上结节状阴影分析通常能区分良性病变（上皮局灶性增生、纤维腺瘤）、早期癌（导管内和小叶原位癌，有时伴有小浸润灶）和浸润性癌。良性病变和癌中的钙化沉积在乳腺钼靶上无差异。上皮增生灶（良性发育异常）、导管内和小叶原位癌与浸润性癌之间存在形态发生联系。在65例不可触及的癌病例中，31例（47.7%）被归类为早期癌，34例（52.3%）为组织学恶性程度相对较低的浸润性癌。两组术后生存率均良好。
