Wright J J, Kydd R R, Lees G J
Biol Cybern. 1984;50(4):273-83. doi: 10.1007/BF00337077.
We have previously proposed that electrocortical activity (EEG) arises as a manifestation of linear waves generated by resonance among telencephalic neurones, and that this activity is controlled in part by ascending neurones from the brain-stem, which regulate the damping of each resonance. The present experiments focus on a specific class of ascending neurones, the mesotelencephalic dopaminergic cells, because these cells are thought to mediate important psychological effects, and are conveniently subject to selective lesion. A critical test of the theory is undertaken, by performing selective unilateral lesion, assessing the changes in the power spectrum of the EEG attributable to lesion, and determining whether the changes in phase of the EEG correspond to that predicted from the changes in power. Results support the theory, although the model order applicable in these experiments in inadequate. The consequences of these findings for automata theory, linear network theory and their application to mammalian brains are briefly discussed.
我们之前曾提出，皮层电活动（脑电图）是端脑神经元之间共振产生的线性波的一种表现形式，并且这种活动部分受来自脑干的上行神经元控制，这些上行神经元调节每次共振的阻尼。目前的实验聚焦于一类特定的上行神经元，即中脑边缘多巴胺能细胞，因为这些细胞被认为介导重要的心理效应，并且便于进行选择性损伤。通过进行选择性单侧损伤、评估损伤引起的脑电图功率谱变化以及确定脑电图相位变化是否与功率变化所预测的一致，对该理论进行了关键测试。结果支持该理论，尽管适用于这些实验的模型阶数不足。简要讨论了这些发现对自动机理论、线性网络理论及其在哺乳动物大脑中的应用的影响。
