Frytak S, Moertel C G, Rubin J
Cancer Treat Rep. 1984 Dec;68(12):1427-31.
The metabolism of oral delta-9-tetrahydrocannabinol (THC) was studied in nine patients with gastrointestinal neoplasms receiving chemotherapy regimens containing 5-FU and semustine. Plasma levels of THC and its metabolites 11-OH-delta-9-THC (11-OH-THC) and 11-nor-9-carboxy-delta-9-THC (C-THC) were measured. Plasma levels of THC and its metabolites were quite variable among the patients studied. Plasma levels of THC and 11-OH-THC tended to peak at the same time; the C-THC levels peaked later and lasted much longer than the others. Mean half-lives of THC, 11-OH-THC, and C-THC were estimated to be 1.5, 2.1, and 4.4 hours, respectively. Multiple doses of THC did not produce a significant additive effect on the plasma concentrations of the biologically active metabolites THC and 11-OH-THC. No correlation between antiemetic effect or cannabinoid toxicity and plasma levels of the three metabolites could be made in this small number of patients.
对9例接受含5-氟尿嘧啶和司莫司汀化疗方案的胃肠道肿瘤患者口服Δ⁹-四氢大麻酚（THC）的代谢情况进行了研究。测定了血浆中THC及其代谢产物11-羟基-Δ⁹-四氢大麻酚（11-OH-THC）和11-去甲-9-羧基-Δ⁹-四氢大麻酚（C-THC）的水平。在研究的患者中，THC及其代谢产物的血浆水平差异很大。THC和11-OH-THC的血浆水平往往同时达到峰值；C-THC水平达到峰值的时间较晚，且持续时间比其他物质长得多。THC、11-OH-THC和C-THC的平均半衰期估计分别为1.5小时、2.1小时和4.4小时。多次服用THC对生物活性代谢产物THC和11-OH-THC的血浆浓度没有产生显著的累加效应。在这少数患者中，无法确定止吐效果或大麻素毒性与三种代谢产物血浆水平之间的相关性。
