γ-氨基丁酸能镇痛：对药物成瘾的γ-氨基丁酸能治疗的启示。

gamma-Aminobutyric acid-ergic analgesia: implications for gamma-aminobutyric acid-ergic therapy for drug addictions.

作者信息

DeFeudis F V

出版信息

Drug Alcohol Depend. 1984 Oct;14(2):101-11. doi: 10.1016/0376-8716(84)90035-8.

Abstract

Recent in vivo and in vitro studies regarding the involvement of gamma-aminobutyric acid (GABA)-ergic systems in analgesia and in opiate dependence have been reviewed and analyzed. It seems evident that GABA-ergic systems play a role in mediating the effects of opiates and that some interplay might exist between endogenous opioid systems and GABA-ergic systems. Systemic administration of GABA-agonists, GABA uptake blockers and inhibitors of GABA-alpha-oxoglutarate transaminase (GABA-T) can produce potent analgesic actions in experimental animals and in man. Further study of such agents might lead to the development of new analgesics and/or new drugs for treating certain types of drug addiction.

摘要

近期有关γ-氨基丁酸（GABA）能系统参与镇痛和阿片类药物依赖的体内和体外研究已得到综述和分析。显然，GABA能系统在介导阿片类药物的作用中发挥作用，并且内源性阿片系统与GABA能系统之间可能存在某种相互作用。在实验动物和人体中，全身性给予GABA激动剂、GABA摄取阻滞剂和GABA-α-酮戊二酸转氨酶（GABA-T）抑制剂可产生强效镇痛作用。对这类药物的进一步研究可能会促成新型镇痛药和/或治疗某些类型药物成瘾的新药的研发。