多巴胺在人体醛固酮和18-羟皮质酮分泌调节中的作用。

Role of dopamine in the regulation of aldosterone and 18-hydroxycorticosterone secretion in man.

作者信息

Sowers J R, Beck F W

出版信息

J Endocrinol Invest. 1984 Oct;7(5):473-9. doi: 10.1007/BF03348453.

Abstract

This study was designed to investigate dopaminergic mechanisms involved in the control of corticosteroid secretion. Administration of the dopamine agonist bromocriptine (2.5 mg three times a day for 4 days) to 10 normal males suppressed (p less than 0.01) plasma 18-hydroxycorticosterone (18-OHB) responses to upright posture, isometric handgrip exercise, furosemide administration and angiotensin II infusion without altering supine blood pressure, electrolytes or plasma cortisol. Plasma 18-OHB responses to adrenocorticotropic hormone infusion were not altered by bromocriptine treatment. These observations suggest that angiotensin-mediated 18-OHB and aldosterone secretion is selectively inhibited by dopaminergic mechanisms. Thus, dopamine and angiotensin II may operate as opposing factors in the control of aldosterone biosynthesis.

摘要

本研究旨在探讨参与皮质类固醇分泌控制的多巴胺能机制。对10名正常男性给予多巴胺激动剂溴隐亭（每天3次，每次2.5毫克，共4天），可抑制（p<0.01）血浆18-羟皮质酮（18-OHB）对直立姿势、等长握力运动、速尿给药和血管紧张素II输注的反应，而不改变仰卧位血压、电解质或血浆皮质醇。溴隐亭治疗未改变血浆18-OHB对促肾上腺皮质激素输注的反应。这些观察结果表明，多巴胺能机制选择性抑制血管紧张素介导的18-OHB和醛固酮分泌。因此，多巴胺和血管紧张素II可能在醛固酮生物合成的控制中起相反作用。