[Radiation-protective effectiveness of ATP and adenosine against high-energy protons].
作者信息
Tikhomirova M V, Iashkin P N, Fedorenko B S, Chertkov K S
出版信息
Kosm Biol Aviakosm Med. 1984 Sep-Oct;18(5):75-7.
PMID:6096628
Abstract
The radioprotective effect of ATP and adenosine was investigated on CBA and C57Bl mice hybrids F1 irradiated with 9 GeV protons. The prophylactic treatment of the animals with ATP at a dose of 350-700 mg/kg increased their survival to 63-80% for LD78-83/30 (7.5-8.0 Gy) and to 40% for LD96/30 (8.5 Gy). The administration of adenosine at a dose of 340 mg/kg, equimolar to 700 mg/kg ATP, increased their survival to 93-100% and 73%, respectively. It was found that ATP produced a favorable effect on the hemopoiesis of irradiated mice.
摘要
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